Related Experiment Video
Updated: Jun 28, 2025
07:36
Laparoscopic Common Bile Duct Exploration in Patients with a Previous History of Biliary Tract Surgery
Published on: February 10, 2023
1.8K
False-negative factors of percutaneous transluminal clamp biopsy for suspected malignant biliary stricture: 194 cases
Chengzhi Zhang1, Yipu Li1, Mengyao Song1
1Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Interventional Therapy Institute of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou City, 450000, Henan Province, China.
Insights Into Imaging
|April 12, 2024
Summary
Percutaneous transluminal clamp biopsy (PTCB) is effective for biliary stricture (BS) diagnosis. Non-cholangiocarcinoma BS is a key factor for false-negative results, aiding clinical interpretation.
Area of Science:
- Interventional Radiology
- Gastroenterology
- Oncology
Background:
- Biliary stricture (BS) diagnosis can be challenging, impacting patient treatment.
- Percutaneous transluminal clamp biopsy (PTCB) is a minimally invasive option for BS evaluation.
- Understanding factors leading to false-negative PTCB results is crucial for accurate diagnosis.
Purpose of the Study:
- To identify predictive factors for false-negative results in biliary stricture diagnosis using PTCB.
- To enhance the clinical utility of PTCB by understanding its limitations.
Main Methods:
- Retrospective analysis of 194 patients with suspected malignant BS undergoing PTCB from 2016-2021.
- Final diagnosis confirmed by postoperative pathology, other tissue evidence, or imaging follow-up.
- Univariate and multivariate regression analyses to identify independent risk factors for false-negative value (FNV).
Main Results:
- PTCB demonstrated 81.8% sensitivity and 100% specificity for BS diagnosis.
- Out of 194 cases, 32 (16.5%) yielded false-negative results.
- Non-cholangiocarcinoma BS was identified as an independent risk factor for FNV (OR 7.5, p<0.01).
Conclusions:
- PTCB is an effective and minimally invasive technique for diagnosing biliary strictures.
- Non-cholangiocarcinoma BS is a significant independent risk factor for false-negative PTCB results.
- Identifying these factors can guide clinical interpretation and improve diagnostic accuracy.
