Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

98
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
98
Reliability and Validity01:29

Reliability and Validity

12.7K
Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
12.7K
Surveys02:16

Surveys

14.8K
Often, psychologists develop surveys as a means of gathering data. Surveys are lists of questions to be answered by research participants, and can be delivered as paper-and-pencil questionnaires, administered electronically, or conducted verbally. Generally, the survey itself can be completed in a short time, and the ease of administering a survey makes it easy to collect data from a large number of people.
14.8K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

363
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
363
Natural Selection and Mating Preferences01:06

Natural Selection and Mating Preferences

101
The principle of natural selection posits that organisms better adapted to their environment are more likely to survive and reproduce. This principle is closely intertwined with mating preferences, a key aspect of sexual selection, which evolutionary psychologists believe is driven by instincts to propagate one's genes. Such instincts significantly influence mating behaviors and preferences between genders.
Females, due to their biological roles in conception, pregnancy, and nursing,...
101

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating PGT-A into PGT-M protocols in young ART-naïve patients undergoing single embryo transfer.

Reproductive biomedicine online·2026
Same author

Unmasking NF1 mosaicism: optical genome mapping identifies a novel t(15;17) translocation in melanocytes.

Journal of medical genetics·2026
Same author

Variant Curation of the Largest Compendium of <i>FOXL2</i> Coding and Noncoding Sequence and Structural Variants in BPES.

Human mutation·2026
Same author

Systematic Disruption of Zebrafish Fibrillin Genes Identifies a Translational Zebrafish Model for Marfan Syndrome.

JACC. Basic to translational science·2026
Same author

Risk management and the further use of gametes from a donor with a known pathogenic variant.

Journal of medical ethics·2026
Same author

ERN GENTURIS guideline on counselling on reproductive options for individuals with a cancer predisposition syndrome (including genturis).

European journal of human genetics : EJHG·2026

Related Experiment Video

Updated: Jun 28, 2025

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

36.8K

Accepting or declining preconception expanded carrier screening: An exploratory study with 407 couples.

Ariane J A G Van Tongerloo1, Hannah Verdin1, Wouter Steyaert1

  • 1Center for Medical Genetics Ghent, University Hospital Ghent, Ghent, Belgium.

Journal of Genetic Counseling
|April 13, 2024
PubMed
Summary

Most couples considering pregnancy accepted expanded carrier screening (ECS) after it was offered. Key factors influencing decisions included age, education, and desire for reproductive information and control.

Keywords:
carrier testingdecision makingpreconception

More Related Videos

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
00:09

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

9.4K
Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

3.1K

Related Experiment Videos

Last Updated: Jun 28, 2025

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

36.8K
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
00:09

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

9.4K
Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

3.1K

Area of Science:

  • Medical Genetics
  • Reproductive Medicine
  • Genetic Counseling

Background:

  • Expanded carrier screening (ECS) utilizes advanced genomic technologies to identify couples at risk for severe genetic disorders in offspring.
  • Preconception ECS aims to inform reproductive choices and facilitate decision-making for prospective parents.
  • Limited data exists on the clinical uptake and decision-making factors associated with preconception ECS.

Purpose of the Study:

  • To describe the characteristics of couples offered preconception ECS at a specific medical genetics center.
  • To identify the reasons couples accepted or declined the BeGECS (Belgian Genetic ECS) test.
  • To understand the uptake of a comprehensive ECS panel in a clinical setting.

Main Methods:

  • A survey was administered to 407 couples offered BeGECS at the Center for Medical Genetics of the University Hospital Ghent (CMGG) between October 2019 and January 2023.
  • Participants completed a questionnaire detailing their decision to accept or decline the test and their motivations.
  • Statistical analysis was performed to compare characteristics between couples who accepted and declined ECS.

Main Results:

  • Of 407 couples offered BeGECS, 270 (66%) accepted and 137 (34%) declined.
  • Couples who accepted the test were significantly older and had higher education levels.
  • Primary reasons for acceptance included prevention, information gathering, reproductive planning, and enhanced control; reasons for declining involved anxiety about information, unchanged reproductive plans, cost concerns, and lack of perceived family history risk.

Conclusions:

  • The majority of preconception couples offered comprehensive ECS accepted the test, indicating a high demand for reproductive genetic information.
  • Demographic factors such as age and education level influence the uptake of ECS.
  • Understanding patient motivations for accepting or declining ECS is crucial for genetic counseling and service provision.