Arrhythmogenic Left Ventricular Cardiomyopathy: From Diagnosis to Risk Management

Area of Science:

• Cardiology
• Genetics
• Pathology

Background:

• Left ventricular arrhythmogenic cardiomyopathy (ALVC) is a rare, poorly understood condition.
• Recently reclassified within non-dilated left ventricular cardiomyopathies.
• Characterized by fibrofatty replacement in the left ventricular myocardium.

Purpose of the Study:

• To review the background of ALVC.
• To outline diagnostic approaches for ALVC.
• To summarize sudden cardiac death (SCD) risk in ALVC patients.

Main Methods:

• Literature review of current evidence.
• Analysis of diagnostic criteria.
• Evaluation of risk stratification strategies.

Main Results:

• ALVC is a distinct left ventricular disease with variable presentation.
• Cardiac magnetic resonance (CMR) and genetic testing are key diagnostic tools.
• Recent guidelines enhance ALVC management and SCD risk stratification.

Conclusions:

• ALVC remains poorly characterized despite recent advances.
• Multiparametric diagnosis is essential for patient management.
• Further research is needed to fully understand ALVC.