Utility Scores for Risk-Reducing Mastectomy and Risk-Reducing Salpingo-Oophorectomy: Mapping to EQ-5D

Area of Science:

• Oncology
• Preventive Medicine
• Health Economics

Background:

• Risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) are highly effective cancer prevention strategies.
• Quality of life assessment is crucial for patient counseling and health-economic evaluations.
• Existing literature lacks published EQ-5D health-related utility scores (HRUSs) post-RRM and post-RRSO.

Purpose of the Study:

• To derive and present the first health-related utility scores (HRUSs) using EQ-5D for patients undergoing risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO).
• To provide essential data for clinicians counseling patients and for health-economic evaluations of these cancer preventive interventions.

Main Methods:

• Utilized aggregate data from a systematic review, converting SF-36/SF-12 scores to EQ-5D HRUSs via a mapping algorithm.
• Employed random-effects meta-analysis to calculate adjusted disutilities and utility scores.
• Performed subgroup analyses comparing long-term versus short-term follow-up outcomes.

Main Results:

• Risk-reducing mastectomy (RRM) is associated with a long-term disutility of -0.08 (95% CI -0.11, -0.04) and a utility of 0.92.
• Risk-reducing salpingo-oophorectomy (RRSO) is associated with a long-term disutility of -0.03 (95% CI -0.05, 0.00) and a utility of 0.97.
• Data derived from four studies (209 patients) for RRM and five studies (742 patients) for RRSO.

Conclusions:

• This study presents the inaugural health-related utility scores for patients following risk-reducing mastectomy and salpingo-oophorectomy.
• Highlights the necessity for high-quality prospective studies to accurately characterize quality of life at various time points after these procedures.