Obesity and Inflammatory Factors in the Progression of Early-Onset Colorectal Cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Obesity-driven inflammation and hormones like leptin and adiponectin promote early-onset colorectal cancer (EOCRC) by altering macrophage metabolism. Understanding these mechanisms may reveal new therapeutic targets for EOCRC prevention and treatment.
Area Of Science
- Oncology
- Immunology
- Metabolism
Background
- Obesity induces chronic inflammation, affecting macrophage metabolism and contributing to cancer development.
- Tumor-associated macrophages produce metabolites like itaconate, influencing cancer progression.
- Obesity-related hormones (leptin, adiponectin) impact macrophage cytokine expression and colorectal cancer via the PI3K/AKT pathway.
Purpose Of The Study
- To review obesity-related hormones and inflammatory mechanisms in early-onset colorectal cancer (EOCRC).
- To explore the role of macrophage metabolism and specific metabolites in EOCRC development.
- To identify potential therapeutic targets for EOCRC based on obesity-driven inflammation.
Main Methods
- Literature search of PubMed and Cochrane databases.
- Keywords included 'EOCRC', 'obesity', 'obesity-related hormones', 'itaconate', 'adiponectin', 'leptin', 'M2a macrophage', and 'microbiome'.
- Review focused on inflammatory markers, hormone signaling, and metabolic alterations in EOCRC.
Main Results
- Obesity-related inflammation and hormones (leptin, adiponectin) are linked to EOCRC progression.
- Metabolites like itaconate and macrophage polarization (M2-like) play roles in tumor suppression and promotion.
- The PI3K/AKT pathway is implicated in obesity-driven EOCRC development.
Conclusions
- Obesity-related inflammation and hormonal changes significantly contribute to early-onset colorectal cancer.
- Targeting these inflammatory and metabolic pathways, potentially with agents like aspirin, could offer therapeutic benefits.
- Further research into these associations may uncover novel strategies for EOCRC prevention and treatment.
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