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Cholecystokinin and gastrin forms in the nervous system
Annals of the New York Academy of Sciences
|January 1, 1985
Summary
Cholecystokinin octapeptide (CCK-8) is prevalent in the brain, unlike gastrins. Brain stem neurons responding to stomach fullness can differentiate between CCK-8 and gastrin, suggesting a role in satiety.
Area of Science:
- Neuroscience
- Gastroenterology
- Molecular Biology
Background:
- Cholecystokinin octapeptide (CCK-8) is the primary gastrin-CCK family member in the central nervous system.
- Other gastrin forms exist in lower concentrations or specific locations.
- The cDNA sequences for CCK and gastrin have been elucidated, enabling detailed study of their biosynthetic pathways.
Purpose of the Study:
- To investigate the differential response of brain stem neurons to CCK-8 and gastrin.
- To explore the role of this neural system in mediating the peripheral satiety effect of CCK.
Main Methods:
- Studied CCK and gastrin presence in the vagus nerve.
- Examined the response of brain stem neurons, receiving input from gastric mechanoreceptors, to CCK-8 and gastrin administration.
Main Results:
- Both CCK and gastrin were detected in the vagus nerve.
- Brain stem neurons responsive to gastric mechanoreceptor input showed a response to CCK-8.
- Most of these neurons did not respond to systemically administered gastrin.
Conclusions:
- The studied neural system can distinguish between CCK-8 and gastrin.
- This system may be involved in mediating the peripheral satiety effects of CCK, highlighting peptide-specific signaling pathways.