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Related Experiment Videos

Hyperphagia: a necessary precondition to obesity?

J M Slattery, R M Potter

    Appetite
    |June 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Obesity can develop even without overeating. Studies show animals prone to weight gain accumulate fat before hyperphagia and can gain weight even when food-restricted, challenging the caloric imbalance theory.

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    Neural networks.

    Lancet (London, England)·1995

    Area of Science:

    • Physiology
    • Metabolism
    • Obesity Research

    Background:

    • Weight gain is commonly attributed to a caloric imbalance caused by hyperphagia (overeating).
    • This assumption often overlooks caloric intake during the initial stages of fat accumulation.
    • Obese individuals frequently overeat, reinforcing the link between overconsumption and weight gain.

    Purpose of the Study:

    • To review literature on the onset of caloric overconsumption relative to weight gain.
    • To investigate fat accumulation during food restriction in animals prone to obesity.
    • To challenge the necessity of hyperphagia in the development of obesity.

    Main Methods:

    • Literature review focusing on studies examining the temporal relationship between caloric intake and weight gain.

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  • Analysis of research on genetically and surgically induced obesity models.
  • Examination of fat accumulation under conditions of food restriction.

    • Main Results:

    • Animals prone to obesity can gain significant weight and fat before exhibiting hyperphagia.
    • Obese animals continue to gain weight even when subjected to subnormal food intake.
    • While overconsumption accelerates weight gain, it is not a prerequisite for fat accumulation in susceptible animals.

    Conclusions:

    • Hyperphagia is not a necessary condition for animals prone to obesity to gain weight and accumulate fat.
    • The development of obesity may involve mechanisms independent of, or preceding, overconsumption.
    • Rethinking the primary drivers of weight gain is crucial for understanding and treating obesity.