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Cyclocurcumin as Promising Bioactive Natural Compound: An Overview
Carla Gasbarri1, Guido Angelini1
1Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini, 66100 Chieti, Italy.
Molecules (Basel, Switzerland)
|April 13, 2024
Summary
Cyclocurcumin, a turmeric compound, exhibits unique reactivity and promising therapeutic potential for degenerative and cardiovascular diseases. However, its clinical use is limited by poor solubility and bioavailability.
Area of Science:
- Natural product chemistry
- Medicinal chemistry
Background:
- Curcumin and cyclocurcumin are natural compounds from turmeric with distinct reactivities.
- Cyclocurcumin possesses unique hydrophobic properties, including fluorescence and aggregation behavior.
Purpose of the Study:
- To investigate the chemical reactivity and biological potential of cyclocurcumin.
- To compare cyclocurcumin with curcumin, another bioactive compound from turmeric.
Main Methods:
- Chemical analysis of reactivity (tautomerism vs. isomerization).
- Characterization of physicochemical properties (hydrophobicity, fluorescence, aggregation).
- Molecular docking for predicting bioactivity (antioxidant, enzyme inhibition, antiviral).
Main Results:
- Cyclocurcumin undergoes trans-cis isomerization, unlike curcumin's tautomerism.
- Cyclocurcumin displays fluorescence, solvatochromism, and forms aggregates in water.
- Molecular docking suggests potential as an antioxidant, enzyme inhibitor, and antiviral agent, particularly for degenerative and cardiovascular diseases.
Conclusions:
- Cyclocurcumin is a bioactive compound with diverse therapeutic potential.
- Low solubility and bioavailability hinder cyclocurcumin's clinical applications.
- Further research is needed to overcome formulation challenges for cyclocurcumin.
Keywords:
bioavailabilitybiological activitycyclocurcumindocking analysisfluorescencephotoisomerizationplatelet aggregationrheumatoid arthritissolvatochromismMore Related Videos
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