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Updated: Jun 28, 2025
08:46
Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
Published on: November 22, 2016
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Organophosphates as Versatile Substrates in Organic Synthesis
1Department of Organic Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Molecules (Basel, Switzerland)
|April 13, 2024
Summary
Organophosphates are versatile reagents in organic synthesis, enabling key transformations like cross-coupling, oxidation, and reduction reactions. This review highlights their crucial role in synthesizing natural compounds and advancing modern synthetic chemistry.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Organophosphates are widely utilized in various chemical transformations.
- Their application in organic synthesis is a rapidly evolving field.
Purpose of the Study:
- To provide a comprehensive review of organophosphate applications in organic synthesis.
- To highlight the versatility and importance of organophosphates in modern synthetic chemistry.
Main Methods:
- Review of literature on organophosphate applications.
- Categorization of reactions including cross-coupling, oxidation, and reduction.
- Emphasis on synthesis of natural compounds.
Main Results:
- Organophosphates are effective in transition-metal-catalyzed and transition-metal-free cross-coupling reactions.
- They are applicable in both oxidation and reduction reactions.
- Demonstrated utility in the synthesis of complex natural products.
Conclusions:
- Organophosphates are indispensable tools in contemporary organic synthesis.
- Their broad applicability underscores their significance in chemical research and development.
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