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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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3-Nitroatenolol: First Synthesis, Chiral Resolution and Enantiomers' Absolute Configuration

Rosa Sparaco1, Pierfrancesco Cinque1, Antonia Scognamiglio1

  • 1Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.

Molecules (Basel, Switzerland)
|April 13, 2024
PubMed
Summary

Researchers synthesized 3-nitroatenolol to investigate potential endothelial nitration of atenolol. This new nitro-beta-blocker probe aids in understanding drug modification in biological systems.

Keywords:
3-nitroatenololNMR absolute configuration assignmentRiguera’s methodchiral HPLC

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