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Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
Research Progress on the Combination of Quorum-Sensing Inhibitors and Antibiotics against Bacterial Resistance
Jiahao Wang1, Xingyue Lu1, Chenjie Wang1
1Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Abstract:
Bacterial virulence factors and biofilm development can be controlled by the quorum-sensing (QS) system, which is also intimately linked to antibiotic resistance in bacteria. In previous studies, many researchers found that quorum-sensing inhibitors (QSIs) can affect the development of bacterial biofilms and prevent the synthesis of many virulence factors. However, QSIs alone have a limited ability to suppress bacteria. Fortunately, when QSIs are combined with antibiotics, they have a better therapeutic effect, and it has even been demonstrated that the two together have a synergistic antibacterial effect, which not only ensures bactericidal efficiency but also avoids the resistance caused by excessive use of antibiotics. In addition, some progress has been made through in vivo studies on the combination of QSIs and antibiotics. This article mainly expounds on the specific effect of QSIs combined with antibiotics on bacteria and the combined antibacterial mechanism of some QSIs and antibiotics. These studies will provide new strategies and means for the clinical treatment of bacterial infections in the future.
Insights
Quorum-sensing inhibitors (QSIs) combined with antibiotics show synergistic antibacterial effects, enhancing treatment efficacy and combating antibiotic resistance. This combination offers a promising strategy for bacterial infections.
Area of Science:
- Microbiology
- Bacterial pathogenesis
- Drug discovery
Background:
- Quorum-sensing (QS) regulates bacterial virulence and biofilm formation, impacting antibiotic resistance.
- Quorum-sensing inhibitors (QSIs) can disrupt these processes but have limited standalone efficacy.
- QS plays a critical role in bacterial communication and virulence.
Purpose of the Study:
- To review the effects of combining QSIs with antibiotics against bacteria.
- To elucidate the combined antibacterial mechanisms of QSIs and antibiotics.
- To explore novel therapeutic strategies for bacterial infections.
Main Methods:
- Literature review of studies on QSIs and antibiotic combinations.
- Analysis of in vitro and in vivo research findings.
- Examination of synergistic antibacterial mechanisms.
Main Results:
- QSIs combined with antibiotics demonstrate enhanced therapeutic effects compared to QSIs alone.
- Synergistic action ensures bactericidal efficiency and mitigates antibiotic resistance.
- In vivo studies support the efficacy of this combined approach.
Conclusions:
- Combining QSIs with antibiotics presents a potent strategy against bacterial infections.
- This approach offers a way to overcome antibiotic resistance.
- Future clinical applications for treating bacterial infections are promising.
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