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Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism
Ruo-Ying Li1,2,3, Liang Guo1,2,3
1School of Exercise and Health, Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai 200438, China.
Regular exercise can help slow diabetic nephropathy (DN) progression by improving blood sugar, blood pressure, and reducing kidney damage markers. Understanding exercise mechanisms is key for effective DN treatment and prevention.
Area of Science:
- Nephrology
- Endocrinology
- Exercise Physiology
Background:
- Diabetic nephropathy (DN) is a severe diabetes complication.
- DN progression is linked to oxidative stress, inflammation, cell death, and fibrosis.
- Drug treatments for DN have limitations.
Purpose of the Study:
- To review the beneficial effects of exercise on diabetic nephropathy (DN).
- To explore the mechanisms by which exercise ameliorates DN.
- To provide insights for developing exercise programs for DN prevention and treatment.
Main Methods:
- Literature review of studies on exercise and diabetic nephropathy.
- Analysis of exercise's impact on key DN indicators.
- Exploration of molecular and physiological pathways involved.
Main Results:
- Exercise is a cost-effective, low-risk intervention for slowing DN progression.
- Exercise improves glycemic control and reduces blood pressure.
- Exercise decreases serum creatinine and albuminuria, mitigating kidney damage.
Conclusions:
- Exercise offers significant benefits for managing and potentially reversing diabetic nephropathy.
- Understanding exercise's multifaceted mechanisms is crucial for clinical application.
- Exercise represents a viable complementary strategy for DN treatment and prevention.
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