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Updated: Jun 28, 2025

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions
Published on: November 9, 2020
Interaction between Oligodendrocytes and Interneurons in Brain Development and Related Neuropsychiatric Disorders
Yingqi Liu1, Jie Yuan1, Yuhao Dong1
1Department of Neuroscience, Air Force Medical University, Xi'an 710032, China.
Abstract:
A variety of neurological and psychiatric disorders have recently been shown to be highly associated with the abnormal development and function of oligodendrocytes (OLs) and interneurons. OLs are the myelin-forming cells in the central nervous system (CNS), while interneurons are important neural types gating the function of excitatory neurons. These two types of cells are of great significance for the establishment and function of neural circuits, and they share similar developmental origins and transcriptional architectures, and interact with each other in multiple ways during development. In this review, we compare the similarities and differences in these two cell types, providing an important reference and further revealing the pathogenesis of related brain disorders.
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