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MicroRNA Associations with Preterm Labor-A Systematic Review

Adrianna Kondracka1, Aleksandra Stupak1, Magda Rybak-Krzyszkowska2

  • 1Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-081 Lublin, Poland.

International Journal of Molecular Sciences
|April 13, 2024
PubMed

Insights

MicroRNAs show promise as diagnostic and prognostic markers for preterm labor. This review highlights their potential for early intervention and improved pregnancy outcomes.

Area of Science:

  • Reproductive Biology
  • Molecular Genetics
  • Biomarkers

Background:

  • Preterm labor is a significant cause of neonatal morbidity and mortality.
  • Current diagnostic and prognostic tools for preterm labor have limitations.
  • MicroRNAs (miRNAs) are emerging as potential biomarkers in various pregnancy complications.

Approach:

  • Systematic review of studies published between 2018 and 2023.
  • Inclusion of 47 relevant studies covering diverse pregnancy scenarios.
  • Rigorous quality assessment and data synthesis.

Key Points:

  • Specific microRNAs demonstrate significant diagnostic potential for preterm labor.
  • Certain miRNAs exhibit robust predictive capabilities for preterm labor risk.
  • miRNAs offer promising avenues for early detection and intervention.

Conclusions:

  • MicroRNAs represent a transformative potential for diagnosing and predicting preterm labor.
  • This review provides a foundation for future research and clinical applications.
  • Further investigation into miRNA biomarkers can lead to improved pregnancy outcomes.
Keywords:
MicroRNA expressionpregnancypreterm labor

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