Related Experiment Video
Updated: Jun 28, 2025
08:40
Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
17.6K
MicroRNA Associations with Preterm Labor-A Systematic Review
Adrianna Kondracka1, Aleksandra Stupak1, Magda Rybak-Krzyszkowska2
1Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-081 Lublin, Poland.
International Journal of Molecular Sciences
|April 13, 2024
Summary
MicroRNAs show promise as diagnostic and prognostic markers for preterm labor. This review highlights their potential for early intervention and improved pregnancy outcomes.
Area of Science:
- Reproductive Biology
- Molecular Genetics
- Biomarkers
Background:
- Preterm labor is a significant cause of neonatal morbidity and mortality.
- Current diagnostic and prognostic tools for preterm labor have limitations.
- MicroRNAs (miRNAs) are emerging as potential biomarkers in various pregnancy complications.
Approach:
- Systematic review of studies published between 2018 and 2023.
- Inclusion of 47 relevant studies covering diverse pregnancy scenarios.
- Rigorous quality assessment and data synthesis.
Key Points:
- Specific microRNAs demonstrate significant diagnostic potential for preterm labor.
- Certain miRNAs exhibit robust predictive capabilities for preterm labor risk.
- miRNAs offer promising avenues for early detection and intervention.
Conclusions:
- MicroRNAs represent a transformative potential for diagnosing and predicting preterm labor.
- This review provides a foundation for future research and clinical applications.
- Further investigation into miRNA biomarkers can lead to improved pregnancy outcomes.
Related Concept Videos
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K