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Microbial Community Changes in Silkworms Suspected of Septicemia and Identification of Serratia sp

Jong Woo Park1, Seul Ki Park1, Chan Young Jeong1

  • 1Department of Agricultural Biology, National Institute of Agricultural Sciences, Wanju-gun, Jeonju 55365, Jeollabuk-do, Republic of Korea.

International Journal of Molecular Sciences
|April 13, 2024
PubMed

Insights

Researchers identified a new bacterial cause of silkworm sepsis. Microbial community analysis revealed imbalances, with increased Proteobacteria and a dominant Serratia sp. linked to disease.

Area of Science:

  • Sericulture
  • Microbiology
  • Animal Pathology

Background:

  • Silkworm diseases like sepsis significantly impact production.
  • Limited research exists on the bacterial causes and microbial community shifts in silkworm sepsis.
  • Understanding these changes is crucial for disease prevention and control.

Purpose of the Study:

  • To investigate the morphological characteristics and microbial community changes in silkworms with sepsis.
  • To identify the specific causative agent of silkworm sepsis.
  • To establish a link between microbial dysbiosis and disease development.

Main Methods:

  • Morphological examination of septic silkworms.
  • 16S rRNA amplicon sequencing for microbial community analysis of healthy and septic silkworms.
  • Bacterial isolation, identification, and oral reinfection experiments.

Main Results:

  • Silkworms with sepsis showed a significant decrease in Firmicutes and an increase in Proteobacteria.
  • A specific Serratia sp. was identified as the dominant bacterium in septic silkworms.
  • This identified Serratia sp. caused a 1.8 times higher mortality rate than Serratia marcescens.

Conclusions:

  • A novel bacterium responsible for silkworm sepsis was identified using microbial community analysis.
  • Silkworm sepsis is associated with a disrupted microbial community balance and aberrant bacterial proliferation.
  • Findings provide insights into silkworm bacterial diseases and potential targets for intervention.
Keywords:
Serratiamicrobial communitysepticemiasilkworm

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