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Association between Intracellular Calcium Signaling and Tumor Recurrence in Human Non-Functioning Pituitary Adenomas.

Yorgui Santiago-Andres1,2, Ana Aquiles3, Keiko Taniguchi-Ponciano4

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|April 13, 2024
PubMed
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Clinically non-functioning pituitary adenomas (CNFPAs) recurrence correlates with cellular responsiveness to hypothalamic hormones. Testing this responsiveness may predict CNFPA behavior and aid in patient management.

Keywords:
CNFPAPitNETcalciumcell signalingendocrine disruptionhormone secretionnon-secreting pituitary adenomasilent pituitary adenoma

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Area of Science:

  • Endocrinology
  • Oncology
  • Cell Biology

Background:

  • Clinically non-functioning pituitary adenomas (CNFPAs) are common sellar tumors.
  • CNFPAs present with compressive symptoms, lacking hormonal hypersecretion.
  • Most CNFPAs show gonadotrope differentiation; few are null cell adenomas.

Purpose of the Study:

  • To investigate intracellular calcium mobilization in CNFPAs.
  • To correlate cellular responsiveness to hypothalamic secretagogues with CNFPA behavior.
  • To explore predictive markers for CNFPA recurrence.

Main Methods:

  • Evaluated basal and stimulated intracellular calcium mobilization in 13 CNFPAs.
  • Assessed spontaneous intracellular calcium activity.
  • Tested response to multiple hypothalamic secretagogues.

Main Results:

  • CNFPA recurrence positively correlates with cellular responsiveness.
  • Spontaneous intracellular calcium activity is linked to recurrence.
  • Responsiveness to multiple hypothalamic secretagogues predicts recurrence.

Conclusions:

  • Cellular responsiveness to hypothalamic secretagogues is a potential predictor of CNFPA recurrence.
  • Testing cellular responsiveness may offer a tool for predicting CNFPA clinicopathologic behavior.
  • Further research can validate this approach for patient management.