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Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
Published on: May 5, 2022
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RETRACTED: Markouli et al. Impact of Histone Modifications and Their Therapeutic Targeting in Hematological
Mariam Markouli1, Dimitrios Strepkos1, Christina Piperi1
1Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
International Journal of Molecular Sciences
|April 13, 2024
Summary
This article on histone modifications and their therapeutic targeting in hematological malignancies has been retracted. The retraction notice does not provide specific reasons for the article
Area of Science:
- Molecular Biology
- Oncology
- Epigenetics
Context:
- Hematological malignancies represent a significant area of clinical oncology research.
- Histone modifications play a crucial role in gene regulation within cancer cells.
- Targeting epigenetic mechanisms offers a promising therapeutic avenue.
Purpose:
- To review the impact of histone modifications in hematological cancers.
- To discuss the therapeutic strategies targeting these modifications.
- To highlight the potential of epigenetic therapies in treating blood cancers.
Summary:
- The article explored the role of histone modifications in the development and progression of hematological malignancies.
- It detailed various therapeutic approaches aimed at targeting these epigenetic alterations.
- The potential clinical applications of these targeted therapies were discussed.
Impact:
- This retraction impacts the scientific literature on epigenetic therapies for blood cancers.
- Researchers should be aware of this retraction when consulting literature on histone modification targeting.
- Further research is needed to validate findings in this area.
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