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Association of anthracycline derivatives with DNA: a fluorescence study

L Valentini, V Nicolella, E Vannini

Il Farmaco; Edizione Scientifica

|June 1, 1985

Abstract:

The DNA affinity for 26 anthracycline derivatives was studied by the quenching fluorescence technique. The stereochemical requirements for DNA intercalation are discussed. The relationship between the DNA affinity and bioactivity is also pointed out.

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