The Hippo signalling pathway and its impact on eye diseases

Area of Science:

• Molecular Biology
• Cell Biology
• Ophthalmology

Background:

• The Hippo signalling pathway is a conserved kinase cascade vital for cell fate, homeostasis, and regeneration.
• Emerging evidence links the Hippo signalling pathway to the development of various ocular diseases.
• Understanding this pathway's role is critical for advancing eye disease research.

Purpose of the Study:

• To systematically review the regulatory and functional roles of mammalian Hippo signalling in eye diseases.
• To consolidate current knowledge on the Hippo pathway's involvement in ocular pathophysiology.
• To identify gaps in research for future investigations.

Main Methods:

• Systematic literature review of experimental and clinical studies.
• Analysis of research on mammalian Hippo signalling systems in the context of eye diseases.
• Synthesis of findings on the pathway's regulatory and functional aspects.

Main Results:

• The Hippo signalling pathway plays a significant role in the pathophysiology of several eye diseases.
• Studies highlight its involvement in processes relevant to ocular health and disease.
• This review is the first to systematically collate this information.

Conclusions:

• The Hippo signalling pathway is a key player in ocular disease development.
• Comprehensive studies are necessary to fully elucidate its mechanisms in eye conditions.
• Targeting the Hippo pathway may offer potential therapeutic strategies for eye diseases.