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Updated: Jun 28, 2025
Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
Published on: June 17, 2016
CD146, a therapeutic target involved in cell plasticity
Zhenzhen Wu1, Yuzhe Zang1,2, Chuyi Li1,2
1CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Abstract:
Since its identification as a marker for advanced melanoma in the 1980s, CD146 has been found to have multiple functions in both physiological and pathological processes, including embryonic development, tissue repair and regeneration, tumor progression, fibrosis disease, and inflammations. Subsequent research has revealed that CD146 is involved in various signaling pathways as a receptor or co-receptor in these processes. This correlation between CD146 and multiple diseases has sparked interest in its potential applications in diagnosis, prognosis, and targeted therapy. To better comprehend the versatile roles of CD146, we have summarized its research history and synthesized findings from numerous reports, proposing that cell plasticity serves as the underlying mechanism through which CD146 contributes to development, regeneration, and various diseases. Targeting CD146 would consequently halt cell state shifting during the onset and progression of these related diseases. Therefore, the development of therapy targeting CD146 holds significant practical value.
Insights
CD146, a marker for advanced melanoma, plays key roles in development, repair, and diseases. Targeting CD146 may halt cell plasticity, offering therapeutic potential for various conditions.
Area of Science:
- Biomarkers
- Cell Biology
- Molecular Medicine
Background:
- CD146 identified as advanced melanoma marker in the 1980s.
- CD146 functions in embryonic development, tissue repair, regeneration, tumor progression, fibrosis, and inflammation.
- CD146 acts as a receptor or co-receptor in multiple signaling pathways.
Purpose of the Study:
- To summarize the research history and diverse roles of CD146.
- To propose cell plasticity as the unifying mechanism for CD146 functions.
- To highlight the therapeutic potential of targeting CD146.
Main Methods:
- Literature review and synthesis of existing research findings.
- Analysis of CD146's involvement in physiological and pathological processes.
- Conceptual framework development linking CD146 to cell plasticity.
Main Results:
- CD146 is implicated in a wide array of biological processes and diseases.
- Cell plasticity is proposed as the core mechanism underlying CD146's multifaceted roles.
- Targeting CD146 shows promise for therapeutic interventions.
Conclusions:
- CD146's involvement in cell plasticity drives its roles in development, regeneration, and disease.
- Halting CD146-mediated cell state shifting is a potential therapeutic strategy.
- Targeting CD146 offers significant practical value for disease treatment.
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