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Age and aging process alter the gut microbes.

Qu Zhanbo1,2,3, Zhuang Jing1,2,3, Han Shugao4

  • 1Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou 313000, Zhejiang, China.

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As people age, their gut microbe composition changes, with specific bacteria increasing or decreasing. These shifts in gut bacteria may be linked to age-related diseases.

Keywords:
agebioinformatics analysisfunctional genesgut microbesmetagenomic sequencing

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Area of Science:

  • Microbiology
  • Gerontology
  • Human Health

Background:

  • Gut microbes and aging are critical factors influencing disease development.
  • The composition of the gut microbial community is demonstrably affected by the aging process.

Purpose of the Study:

  • To analyze time-dependent gut microbe profiles in individuals over 45 years old.
  • To investigate the correlation between aging and gut microbial composition.

Main Methods:

  • Analysis of fecal samples from 510 healthy individuals aged over 45.
  • Utilized diversity indices (Shannon, Simpson, Ace) and beta diversity analysis (NMDS) for gut microbe assessment.
  • Employed random forest (RF) and linear discriminant analysis (LDA) to identify characteristic microbes and their abundance changes with age.

Main Results:

  • Individuals aged 45-49 exhibited the highest gut bacterial richness.
  • Identified 15 characteristic gut microbes, including Siphoviridae and Bifidobacterium breve.
  • Observed age-related changes in microbial abundance: Ligiactobacillus and Microviridae increased in those >65, while Blautia_A massiliensis, Lubbockvirus, and Enterocloster clostridioformis decreased, and Klebsiella variicola and Prevotella increased.

Conclusions:

  • Distinct gut microbial profiles are associated with different age groups.
  • Alterations in gut microbial community structure may play a role in age-related diseases.