Related Experiment Video
Updated: Jul 20, 2026
08:51
A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
14.4K
Long-term outcome of multilayer flow modulator in aortic aneurysms
Karlo Pintaric1,2, Lucka Boltezar3,4, Nejc Umek5
1Clinical Institute of Radiology, University Medical Center Ljubljana, Slovenia.
Radiology and Oncology
|April 13, 2024
Summary
Multilayer flow modulators (MFMs) show promise for high-risk aortic aneurysm patients by stabilizing hemodynamics. However, they do not consistently reduce aneurysm size, necessitating long-term monitoring.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Biomedical Engineering
Background:
- Investigated endovascular treatment efficacy using multilayer flow modulators (MFMs) for aortic aneurysms in high-risk patients.
- Patients were unsuitable for conventional surgical or endovascular treatments.
Purpose of the Study:
- To evaluate the efficacy of MFMs in treating aortic aneurysms in high-risk patients.
- To assess hemodynamic changes and aneurysm size modifications post-MFM treatment.
Main Methods:
- Retrospective observational study of 17 high-risk patients from 2011-2019.
- MFM implantation followed by CT angiography for follow-up.
- Analysis of aneurysm volume, flow volume, diameter, technical success, and complications.
Main Results:
- 100% technical success rate with a 17.6% 30-day complication rate.
- 11 of 17 patients demonstrated decreased aneurysm flow volume (median 8% reduction).
- No consistent reduction in aneurysm size; median increase in volume (46 ml) and diameter (18 mm).
Conclusions:
- MFMs provide a potential alternative for high-risk aortic aneurysm patients, stabilizing hemodynamics.
- MFM effectiveness in preventing aneurysm expansion is limited.
- Long-term monitoring is crucial for patients treated with MFMs.
Related Concept Videos
01:15Aortic Regurgitation I: Introduction
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
01:25Aortic Regurgitation III: Medical Management
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
01:26Aneurysm III: Interprofessional Care
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...