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Extensively drug-resistant Salmonella Typhi leading to relapsed urinary tract infection: A case report

Muhammad Yasir1, Muzeer Ahmed1, Muhammad Ateeb Sheikh1

  • 1Department of Internal Medicine, Indus Hospital and Health Network, Karachi, Pakistan.

Diagnostic Microbiology and Infectious Disease
|April 13, 2024
PubMed

Insights

Salmonella Typhi urinary tract infections are rare, especially with extensively drug-resistant strains. This case highlights challenges in managing relapsed infections in older adults.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Urology

Background:

  • Salmonella enterica serotype Typhi (S Typhi) typically causes enteric fever.
  • Urinary tract infections (UTIs) due to S Typhi are uncommon, representing <1% of all UTIs.
  • Pre-existing conditions like immunosuppression or urogenital abnormalities predispose individuals to S Typhi UTIs.

Observation:

  • A 74-year-old male presented with a relapsed urinary tract infection.
  • The patient had a confirmed infection with extensively drug-resistant Salmonella Typhi.
  • This represents the first documented case of its kind.

Findings:

  • Extensively drug-resistant S Typhi can cause recurrent and challenging UTIs.
  • The emergence of such resistant strains in Pakistan complicates treatment strategies.
  • This case underscores the need for vigilance in diagnosing and managing S Typhi UTIs.

Implications:

  • Highlights the growing threat of antimicrobial resistance in S Typhi.
  • Emphasizes the importance of considering S Typhi in UTI cases, particularly in endemic regions.
  • Informs therapeutic approaches for complex and relapsed S Typhi UTIs in older adults.
Keywords:
Extremely drug resistantSalmonella TyphiUrinary tract infection

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