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Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

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Published on: January 5, 2024

Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.

Brent W Stewart¹, Michael L Keaser¹, Hwiyoung Lee²

¹Department of Neural and Pain Sciences, University of Maryland School of Dentistry, W Baltimore Street, Baltimore, MD 21201, USA.

Current Biology : CB

|April 13, 2024

Summary

Chronic pain disrupts cognitive networks. This study reveals pathological claustrum activity in migraine patients, suggesting a brain circuit mechanism for cognitive deficits in chronic pain.

Keywords:

BOLD fMRI DCM DWI clinical research cognition cognitive control cortical networks effective connectivity executive function headache

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Area of Science:

Neuroscience
Cognitive Neuroscience
Pain Research

Background:

Chronic pain is linked to cognitive network dysfunction.
The precise mechanisms driving these cognitive deficits remain unclear.
The claustrum's role in cognitive modulation during pain is under-investigated.

Purpose of the Study:

To investigate the role of the claustrum in cognitive network alterations associated with chronic pain.
To identify specific brain regions and circuits involved in pain-related cognitive impairments.
To explore the neural underpinnings of cognitive deficits in migraine patients.

Main Methods:

Functional magnetic resonance imaging (fMRI) to observe brain activity during pain and cognitive tasks.
Dynamic causal modeling (DCM) to infer directed connectivity between brain regions.
Diffusion-weighted imaging (DWI) to assess structural connectivity.

Main Results:

The claustrum is activated by acute pain and predictive cues in healthy individuals.
Migraine patients exhibit pathological claustrum and right dorsolateral prefrontal cortex (piDLPFC) activity during pain and cognitive tasks.
DCM analysis indicates a directional influence from the claustrum to the piDLPFC, supported by structural connectivity.

Conclusions:

The claustrum plays a role in modulating cognitive networks during acute pain.
Altered claustrum-piDLPFC circuit activity may underlie cognitive impairments in chronic pain, particularly migraine.
These findings offer a potential circuit-level mechanism for cognitive dysfunction in chronic pain conditions.