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FLNA overexpression promotes papillary thyroid cancer aggression via the FAK/AKT signaling pathway

  • 0Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Endocrine Connections +

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April 13, 2024

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April 13, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Filamin A (FLNA) is upregulated in papillary thyroid cancer (PTC), correlating with advanced stages and poorer outcomes. Inhibiting FLNA reduced PTC cell migration and invasion, suggesting FLNA as a potential therapeutic target.

Area Of Science

  • Oncology
  • Molecular Biology
  • Cancer Genomics

Background

  • Filamin A (FLNA) is implicated in various cancers, but its role in papillary thyroid cancer (PTC) is largely unknown.
  • Understanding FLNA's function in PTC is crucial for developing new treatment strategies.

Purpose Of The Study

  • To investigate the expression, clinical significance, and biological function of Filamin A (FLNA) in papillary thyroid cancer (PTC).
  • To explore the potential of FLNA as a therapeutic target for PTC.

Main Methods

  • Analysis of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data for FLNA expression in PTC.
  • qRT-PCR, Kaplan-Meier survival analysis, Transwell assays, wound healing assays, Gene Set Enrichment Analysis (GSEA), and Western blotting were employed.
  • Exploration of the association between FLNA expression and the tumor immune microenvironment (TME).

Main Results

  • FLNA expression was significantly elevated in PTC tissues and correlated with advanced TNM, T, and N stages.
  • High FLNA levels were associated with shorter disease-free interval (DFI) and progression-free interval (PFI).
  • FLNA knockdown suppressed PTC cell migration, invasion, and epithelial-mesenchymal transition (EMT), impacting the FAK/AKT pathway and TME.

Conclusions

  • Filamin A (FLNA) is a significant biomarker for advanced PTC and poor prognosis.
  • FLNA plays a critical role in PTC progression, migration, and invasion.
  • FLNA represents a promising novel therapeutic target for papillary thyroid cancer.

Keywords:

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