Related Experiment Video

Updated: Jun 28, 2025

Simple Continuous Glucose Monitoring in Freely Moving Mice
03:25

Simple Continuous Glucose Monitoring in Freely Moving Mice

Published on: February 24, 2023

5.4K

Association of Fructosamine Levels With Glycemic Management in Children With Type 1 Diabetes as Determined by

Kate C Verbeeten1, Ken Tang2, Jennilea M Courtney1

  • 1CHEO Research Institute, Ottawa, Ontario, Canada.

Canadian Journal of Diabetes
|April 13, 2024
PubMed

Insights

Serum fructosamine correlates with average blood glucose in children with type 1 diabetes. This finding offers a clinical tool for assessing short-term glycemic control when continuous glucose monitoring (CGM) is unavailable.

Area of Science:

  • Pediatric Endocrinology
  • Diabetes Management
  • Biochemical Markers

Background:

  • Type 1 diabetes management requires accurate glucose monitoring.
  • Continuous Glucose Monitoring (CGM) provides real-time glucose data.
  • Serum fructosamine is a marker of short-term glycemic control.

Purpose of the Study:

  • To determine the correlation between serum fructosamine and average blood glucose measured by CGM.
  • To evaluate the clinical utility of fructosamine in pediatric type 1 diabetes.

Main Methods:

  • Analysis of 97 blood samples from 70 children with type 1 diabetes.
  • Utilized 3 weeks of CGM data with at least 60% adherence per participant.
  • Employed ordinary least-squares linear regression with restricted cubic splines.

Main Results:

  • A statistically significant association was found between serum fructosamine and mean blood glucose (F=9.543, p<0.001).
  • A formula and conversion chart were developed to estimate mean blood glucose from fructosamine levels.

Conclusions:

  • Serum fructosamine demonstrates a complex relationship with average blood glucose from CGM.
  • Fructosamine can serve as a clinically valuable tool for short-term glycemic assessment in the absence of CGM.
Abstract

Keywords:
continuous glucose monitoringcontrôle glycémiquediabète de type 1fructosamineglycemic managementpediatricspédiatriesurveillance continue du glucosetype 1 diabetes

More Related Videos

Improving IV Insulin Administration in a Community Hospital12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

18.8K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

220

Related Concept Videos

Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
275
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
257
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
528
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
1.6K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K