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Clinical profile of functional constipation in Saudi children
Mohammad El Mouzan1, Mohammed Kambal1, Hayfa Alabdulkarim1
1From the Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia.
Polyethylene glycol (PEG) is more effective and better tolerated than lactulose for treating functional constipation in Saudi children. Compliance with treatment is key to a positive clinical response in pediatric functional constipation management.
Area of Science:
- Pediatric Gastroenterology
- Clinical Pharmacology
Background:
- Functional constipation (FC) is prevalent in children.
- Limited data exists on FC clinical characteristics in Saudi pediatric populations.
Purpose of the Study:
- To delineate the clinical profile of functional constipation in Saudi children.
- To compare the efficacy and tolerability of polyethylene glycol (PEG) versus lactulose for FC management.
Main Methods:
- Retrospective study including 370 Saudi children diagnosed with FC (Rome IV criteria).
- Data on demographics, clinical features, and treatment response were collected.
- Statistical analysis used descriptive statistics and Pearson's chi-squared test.
Main Results:
- The median age of onset was 4 years; 14% were under one year old.
- Abdominal pain was the most frequent associated symptom (44%).
- Polyethylene glycol (PEG) demonstrated significantly better tolerability (P=.0008) and effectiveness (P<.0001) compared to lactulose.
Conclusions:
- Polyethylene glycol (PEG) is recommended as the first-line treatment for functional constipation in Saudi children.
- Treatment compliance emerged as the sole significant predictor of clinical response.
- Further prospective research is warranted to explore non-compliance factors.
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