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Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...

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Related Experiment Video

Updated: Jun 28, 2025

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Rethinking the role of microglia in obesity.

G Cutugno¹, E Kyriakidou¹, A Nadjar²

¹University of Bordeaux, INSERM, Neurocentre Magendie, Bordeaux, France.

Neuropharmacology

|April 14, 2024

Summary

This summary is machine-generated.

Microglia, the brain's immune cells, are influenced by diet and play a role in obesity. This review explores their metabolic changes and effects on appetite control in the hypothalamus.

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Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity

Published on: October 25, 2016

Area of Science:

Neuroimmunology
Metabolic Neuroscience

Background:

Microglia are central nervous system (CNS) macrophages crucial for brain homeostasis.
They respond to diverse signals, including nutrients and dietary changes, impacting obesity development.
Existing reviews are numerous; this work offers novel perspectives on microglial roles.

Purpose of the Study:

To review current understanding of microglial energy metabolism in obesity.
To examine microglial influence on hypothalamic neurons controlling food intake.
To explore mechanisms behind obesity-related sexual dimorphism.

Main Methods:

Literature review focusing on studies in the arcuate nucleus of the hypothalamus.
Analysis of recent data on microglial metabolic shifts due to obesogenic diets.
Synthesis of findings on microglial-neuron interactions and sexual dimorphism.

Main Results:

Obesogenic diets alter microglial energy metabolism.
These metabolic changes impact hypothalamic neuron activity and food intake regulation.
Sexual dimorphism in obesity is partly mediated by microglial mechanisms.

Conclusions:

Microglia are key players in diet-induced obesity via metabolic and signaling pathways.
Understanding microglial function in the hypothalamus is critical for metabolic health.
Further research is needed to fully elucidate microglial roles in energy metabolism.