In-vitro activity of Sch 34343 against anaerobic bacteria

The in-vitro activity of Sch 34343, was compared with that of imipenem against 226 strains of anaerobic bacteria. Sch 34343 was identical in activity to imipenem, inhibiting 99.5% of the organisms tested at 16 mg/l (the breakpoint for both drugs). Imipenem was slightly more active than Sch 34343 against Bacteroides, Fusobacterium and Veillonella, although both drugs inhibited all organisms in these groups below breakpoint levels.