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Updated: Jun 28, 2025

Intracellular Staining and Flow Cytometry to Identify Lymphocyte Subsets within Murine Aorta, Kidney and Lymph Nodes in a Model of Hypertension
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Higher Mortality in Patients With Diffuse Large B-cell Lymphoma Pre-Existing Arterial Hypertension-Real World Data of

Sebastian Szmit1, Monika Długosz-Danecka2, Joanna Drozd-Sokołowska3

  • 1Department of Cardio-Oncology, Chair of Hematology and Transfusion Medicine, Centre of Postgraduate Medical Education, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.

Heart, Lung & Circulation
|April 15, 2024
PubMed

Insights

Arterial hypertension (AH) significantly predicts premature cardiovascular mortality in diffuse large B-cell lymphoma (DLBCL) patients, independent of age. This highlights AH as a key factor for surveillance in cardio-oncology.

Area of Science:

  • Cardio-oncology
  • Hematology
  • Cardiovascular Medicine

Background:

  • Arterial hypertension (AH) is a recognized risk factor in cardio-oncology.
  • The prognostic significance of AH in diffuse large B-cell lymphoma (DLBCL) requires further long-term evaluation.

Purpose of the Study:

  • To assess the long-term prognostic value of pre-existing arterial hypertension (AH) in patients with diffuse large B-cell lymphoma (DLBCL).

Main Methods:

  • Analysis of data from the Polish Lymphoma Research Group on DLBCL patients treated with first-line rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone.
  • Exclusion of patients with other cardiovascular comorbidities or premature chemotherapy discontinuation due to toxicity.

Main Results:

  • Pre-existing AH was found in 28% of DLBCL patients and was associated with significantly shorter overall survival.
  • Cardiovascular deaths were markedly higher in patients with AH (38.5% vs 3.6%).
  • Multivariate analysis identified AH as an independent predictor of all-cause and cardiovascular mortality.

Conclusions:

  • Arterial hypertension is a significant, age-independent predictor of premature cardiovascular mortality in DLBCL patients.
  • The strong predictive role of AH suggests its utility in guiding surveillance strategies within cardio-oncology clinics.
Abstract

Keywords:
Arterial hypertensionCardio-oncologyCardiotoxicityDiffuse large B-cell lymphomaMortalityOutcomes

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