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Strategies for Improving Impaired Osseointegration in Compromised Animal Models.

J Deng1, C Van Duyn1, D J Cohen1

  • 1Department of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA, USA.

Journal of Dental Research
|April 15, 2024
PubMed
Summary
This summary is machine-generated.

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24R,25(OH)<sub>2</sub>D<sub>3</sub> regulates tumorigenesis in estrogen sensitive laryngeal cancer cells via membrane-associated receptor complexes in ER+ and ER- cells.

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Non-Canonical Wnt16 and microRNA-145 Mediate the Response of Human Bone Marrow Stromal Cells to Additively Manufactured Porous 3-Dimensional Biomimetic Titanium-Aluminum-Vanadium Constructs.

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Surface modifications enhance dental implant osseointegration in patients with poor bone quality. Strategies mimicking bone topography improve bone-to-implant contact (BIC) and osteogenic activity.

Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Cell Biology

Background:

  • Systemic conditions like osteoporosis and diabetes impair implant osseointegration.
  • Reduced bone-to-implant contact (BIC) and bone mineral density are observed in compromised bone quality.
  • Disrupted intercellular communication underlies adverse effects on osseointegration.

Purpose of the Study:

  • To review advances in titanium surface modifications for improving implant osseointegration.
  • To explore the use of surface modifications alone and with therapeutics in animal models.
  • To provide clinically translatable perspectives for compromised patients.

Main Methods:

  • Investigated micro-, meso-, and nanoscale surface modifications of titanium implants.
Keywords:
bone diseasesbone regenerationbone-implant interfacediabetes mellitusmetabolicosteoporosissurface propertiestype 2

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  • Examined the effects of hydrophilicity and topography mimicking osteoclast resorption pits.
  • Assessed outcomes in animal models of human diseases affecting bone quality.

    • Main Results:

    • Surface modifications significantly improve osseointegration by enhancing osteoblast proliferation and differentiation.
    • Modified surfaces promote angiogenesis and modulate osteoclast activity for net bone formation.
    • Surface properties influence communication between bone marrow stromal and immunomodulatory cells.

    Conclusions:

    • Titanium surface modifications are effective in improving BIC and osteogenic activity.
    • Combined approaches using surface modifications, bioactive coatings, and therapeutics offer pragmatic solutions.
    • These strategies enhance long-term implant performance in patients with compromised bone quality.