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Nanodelivery Approaches of Phytoactives for Skin Cancers: Current and Future Perspectives
Evren Algın Yapar1, Merve Nur Ozdemir1, Meltem Ezgi Durgun2
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Türkiye.
Abstract:
In recent years, there has been an increase in skin cancers due to external factors, especially environmental factors, and studies on treatment alternatives have gained importance. Nanomaterials are common, from sunscreen formulas to formulations designed to treat skin cancers at various stages. Using bioactives has multiple effects in treating skin cancers, which provides many advantages. In this regard, many phytochemicals gain importance with their antioxidant, anti-proliferative, anti-inflammatory, antiangiogenic, and analgesic effects. Their delivery with nanocarriers is on the agenda for phytochemicals to gain the targeted stability, effectiveness, and toxicity/safety properties. This review presents types of skin cancers, phytochemicals effective in skin cancers, and their nanocarrier-loaded studies from an up-to-date perspective.
Insights
This review explores using nanomaterial-delivered phytochemicals for skin cancer treatment. These natural compounds offer antioxidant and anti-cancer benefits, enhancing treatment efficacy and safety.
Area of Science:
- Dermatology and Nanomedicine
- Oncology and Phytochemistry
Background:
- Rising incidence of skin cancers linked to environmental factors.
- Growing importance of alternative treatment strategies.
- Nanomaterials and bioactive compounds show promise in dermatological applications.
Purpose of the Study:
- To review skin cancer types.
- To identify effective phytochemicals for skin cancer treatment.
- To summarize nanocarrier-based delivery systems for these phytochemicals.
Main Methods:
- Literature review of skin cancer types.
- Analysis of phytochemicals with therapeutic effects (antioxidant, anti-proliferative, anti-inflammatory, antiangiogenic, analgesic).
- Examination of nanocarrier systems for enhanced phytochemical delivery.
Main Results:
- Phytochemicals exhibit significant anti-cancer properties.
- Nanocarrier systems improve stability, efficacy, and safety of phytochemicals.
- Various nanocarrier-loaded phytochemical studies are emerging.
Conclusions:
- Nanoparticle delivery enhances the therapeutic potential of phytochemicals against skin cancers.
- This approach offers a promising avenue for developing novel, effective, and safer skin cancer treatments.
- Further research into nanocarrier-phytochemical synergy is warranted.
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