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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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Related Experiment Video

Updated: Jun 28, 2025

Expansion and Enrichment of Gamma-Delta &#947;&#948; T Cells from Apheresed Human Product
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Empowering γδ T-cell functionality with vitamin C.

Dieter Kabelitz1,2, Lea Cierna1, Claudia Juraske3,4

  • 1Institute of Immunology, Christian-Albrechts University and University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.

European Journal of Immunology
|April 15, 2024
PubMed
Summary

Vitamin C (ascorbic acid) enhances the cancer-fighting capabilities of gamma delta T cells. This review explores how vitamin C boosts these immune cells for improved cancer immunotherapy.

Keywords:
Adoptive cell therapyImmunotherapyVitamin Cγδ T cells

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Area of Science:

  • Immunology
  • Oncology
  • Biochemistry

Background:

  • Vitamin C (ascorbic acid) is a vital antioxidant and enzyme cofactor.
  • It exhibits direct anti-tumor effects on cancer cells, including colorectal carcinoma.
  • Vitamin C influences the differentiation and function of various immune cells.

Purpose of the Study:

  • To review the immunomodulatory mechanisms of Vitamin C.
  • To focus on how Vitamin C enhances gamma delta (γδ) T cell effector functions.
  • To discuss clinical applications of Vitamin C in adoptive cell therapies.

Main Methods:

  • Literature review of Vitamin C's effects on immune cells.
  • Analysis of Vitamin C's role in enhancing γδ T cell activity.
  • Exploration of clinical strategies for Vitamin C in immunotherapy.

Main Results:

  • Vitamin C modulates immune cell differentiation and function.
  • It enhances the effector functions of γδ T cells.
  • Vitamin C shows potential for boosting cancer immunotherapy efficacy.

Conclusions:

  • Vitamin C possesses significant immunomodulatory properties.
  • It can enhance the anti-cancer potential of γδ T cells.
  • Future clinical applications may leverage Vitamin C to improve adoptive cell therapies.