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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
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A specific and portable gene expression program underlies antigen archiving by lymphatic endothelial cells
Ryan M Sheridan1, Thu A Doan2,3, Cormac Lucas4
1Department of Biochemistry and Molecular Genetics, RNA Bioscience Initiative, University of Colorado School of Medicine.
Biorxiv : the Preprint Server for Biology
|April 15, 2024
Summary
Lymphatic endothelial cells (LECs) in lymph nodes archive antigens, improving immune responses. Researchers identified a unique transcriptional program in these cells that predicts their antigen-archiving capacity.
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Background:
- Protein subunit vaccines induce immune responses by transporting antigens to lymph nodes.
- Lymphatic endothelial cells (LECs) within lymph nodes play a role in antigen archiving and subsequent immune response modulation.
- Understanding the mechanisms of durable antigen archiving by LECs is crucial for vaccine development.
Conclusions:
- Discovered a unique transcriptional program in LECs that underpins durable antigen archiving.
- This finding provides a novel mechanism for enhancing vaccine-induced immune responses.
- The identified transcriptional signature offers a translatable biomarker for antigen archiving capacity across systems.
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