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Published on: June 2, 2014
Efficacy of Probiotics in Prevention of Migraine Attacks in Children: A Randomized Clinical Trial Study
Hassan Bazmamoum1, Bentolhoda Keshtkarsohi2, Younes Mohammadi3
1Department of Pediatric Gastroenterology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
Insights
Probiotics significantly reduced headache frequency and severity in children with migraine, improving parental satisfaction. This study highlights probiotics as a beneficial addition to pediatric migraine treatment.
Area of Science:
- Pediatric Neurology
- Gastroenterology
- Microbiome Research
Background:
- Migraine is a prevalent chronic neurological disorder in children.
- Previous research on probiotic efficacy for pediatric migraine prophylaxis yielded inconsistent results.
- This study addresses the need for evidence-based complementary therapies for childhood migraine.
Purpose of the Study:
- To evaluate the effectiveness of probiotics as an adjunct therapy for migraine prevention in children.
- To compare headache frequency, duration, and severity between children receiving probiotics and placebo.
- To assess parental satisfaction with migraine treatment in both groups.
Main Methods:
- A randomized controlled trial involving 41 children (aged 5-15) diagnosed with migraine.
- Intervention group received propranolol plus a daily 250mg Yomogi probiotic capsule for three months.
- Control group received propranolol plus a placebo for three months. Headache days, PedMIDAS scores, and parental satisfaction were assessed pre- and post-treatment.
Main Results:
- The probiotic group showed a statistically significant greater reduction in headache days (P=0.045).
- Post-treatment PedMIDAS scores were significantly lower in the probiotic group (3.9 ± 3.8) compared to the placebo group (8.4 ± 8.2) (P=0.047).
- Parental satisfaction was significantly higher in the probiotic group (94.4%) versus the placebo group (54.5%) (P=0.011), with no significant adverse events.
Conclusions:
- Adding probiotics to standard migraine treatment in children significantly reduces headache frequency and severity.
- Probiotic supplementation enhances parental satisfaction with migraine management in pediatric patients.
- Yomogi probiotics represent a safe and effective complementary option for pediatric migraine prophylaxis.
Objectives:
Migraine is a chronic and joint disease in children. The results of previous studies on the effectiveness of probiotics in preventing migraine attacks in children have been controversial. This study aims to investigate the effect of probiotics on migraine prophylaxis in children.
Materials & Methods:
In this clinical trial study, 41 children aged 5 to 15 with migraine enrolled the study in two control and intervention groups. Children in the intervention group (18 children) received propranolol at a dose of 1 mg per kilogram of body weight daily in two divided doses along with a 250 mg Yomogi capsule daily for three months, and children in the control group (23 children), received propranolol along with placebo for three months. The study compared the frequency and duration of headache days, PedMIDAS criteria, and parental satisfaction between the two groups before treatment, as well as one month and three months post-treatment.
Results:
The number of headache days in both groups decreased over time, but in the intervention group, this decrease was more than the control group was statistically significant (P=0.045). The average PedMIDAS scale after treatment in the intervention group was 3.9 ± 3.8; in the control group, it was 8.4 ± 8.2, which was statistically significant (P=0.047). Parents' satisfaction with the treatment was statistically significantly higher in the intervention group (94.4%) than in the control group (54.5%) (P=0.011). No significant drug complications were seen in any of the two groups.
Conclusion:
In children with migraine, adding probiotics to migraine treatment reduces the intensity and number of days of children's headaches and increases the Parents' satisfaction with the treatment.
