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Updated: Jun 28, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

424

Mitochondrial ribosomal protein S24 is associated with immunosuppressive microenvironment and cold tumor in lung

Yanni Gao1, Yilin Yu2, Haixia Wu3

  • 1Department of Clinical Laboratory, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.

Heliyon
|April 15, 2024
PubMed
Abstract

Insights

Mitochondrial Ribosomal Protein S24 (MRPS24) is elevated in lung adenocarcinoma (LUAD) and linked to poorer prognosis. Its expression correlates with methylation and immune cell infiltration, suggesting MRPS24 as a potential biomarker for LUAD immunotherapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Mitochondrial ribosomal proteins are crucial for mitochondrial protein synthesis.
  • The role of Mitochondrial Ribosomal Protein S24 (MRPS24) in lung adenocarcinoma (LUAD) remains largely unexplored.
  • Understanding MRPS24's function in LUAD is vital for identifying new therapeutic targets.

Purpose of the Study:

  • To investigate the expression patterns of MRPS24 in LUAD.
  • To elucidate the prognostic significance and immunological mechanisms of MRPS24 in LUAD.
  • To explore the relationship between MRPS24, methylation, and the tumor microenvironment in LUAD.

Main Methods:

  • Utilized TCGA, UCSC Xena, GEO, HPA, GEPIA, cBioPortal, MethSurv, TIMER, TIMER2.0, and TISIDB databases for comprehensive analysis.
  • Assessed MRPS24 expression, clinical features, prognosis, genetic alterations, copy number variations, and methylation.
  • Investigated functional associations with cell cycle, immune infiltration, and methylation patterns.

Main Results:

  • MRPS24 expression was significantly higher in LUAD tissues compared to normal tissues.
  • High MRPS24 expression served as an independent prognostic factor for LUAD.
  • MRPS24 expression inversely correlated with methylation levels and immune cell infiltration, with low methylation associated with worse prognosis.

Conclusions:

  • MRPS24 expression is significantly associated with LUAD prognosis, tumorigenesis, and immune cell infiltration.
  • MRPS24 may function as a potential immune-related biomarker in LUAD development and treatment.
  • MRPS24 shows promise as a predictive biomarker for immunotherapy response in LUAD patients.
Keywords:
Cold tumorCopy number variationsImmunosuppressive microenvironmentLung adenocarcinomaMRPS24

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