Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

1.5K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.5K
Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

150
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
150

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SHOC2 Is a Novel Cause of Central Conducting Lymphatic Anomaly.

American journal of medical genetics. Part A·2026
Same author

Interpretable fine-tuned large language models facilitate making genetic test decisions for rare diseases.

NPJ digital medicine·2026
Same author

Lymphatic Complications in Congenital Heart Disease.

Seminars in roentgenology·2026
Same author

Technical Success and Adverse Events Associated With Percutaneous Carotid Artery Access for Transcatheter Procedures in Infants.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026
Same author

Interpretable Fine-tuned Large Language Models Facilitate Making Genetic Test Decisions for Rare Diseases.

medRxiv : the preprint server for health sciences·2026
Same author

The 9th International RASopathies Symposium.

American journal of medical genetics. Part A·2026

Related Experiment Video

Updated: Jun 28, 2025

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.4K

Central conducting lymphatic anomaly: from bench to bedside.

Luciana Daniela Garlisi Torales1, Benjamin A Sempowski1, Georgia L Krikorian1

  • 1Unit on Vascular Malformations, Division of Intramural Research, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA.

The Journal of Clinical Investigation
|April 15, 2024
PubMed
Summary

Central conducting lymphatic anomaly (CCLA) is a complex lymphatic disorder. Advances in imaging and genomics have improved CCLA diagnosis, genetic understanding, and personalized treatment approaches.

More Related Videos

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs
06:25

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs

Published on: March 5, 2016

9.5K
The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
13:17

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

Published on: March 6, 2015

28.6K

Related Experiment Videos

Last Updated: Jun 28, 2025

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.4K
Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs
06:25

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs

Published on: March 5, 2016

9.5K
The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
13:17

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

Published on: March 6, 2015

28.6K

Area of Science:

  • Medical Genetics
  • Vascular Biology
  • Pediatric Cardiology

Background:

  • Central conducting lymphatic anomaly (CCLA) presents diagnostic and therapeutic challenges.
  • CCLA involves complex abnormalities of the central lymphatic system.
  • Clinical manifestations include fetal hydrops, chylothorax, chylous ascites, and lymphedema.

Purpose of the Study:

  • To review recent advances in the diagnosis and treatment of CCLA.
  • To highlight the role of novel imaging and genomic technologies.
  • To discuss the implications of genetic findings and model systems for personalized medicine.

Main Methods:

  • Dynamic contrast magnetic resonance lymphangiography for improved imaging.
  • Deep sequencing and cell-free DNA analysis for genetic diagnosis.
  • In vitro and in vivo experimental models to elucidate pathogenesis.

Main Results:

  • Enhanced diagnostic accuracy through advanced imaging and genomics.
  • Identification of genetic causes and underlying pathogenesis of CCLA.
  • Development of personalized medicine strategies based on genotype-phenotype correlations.

Conclusions:

  • Recent scientific advancements have significantly improved CCLA diagnosis and understanding.
  • Genetic insights and model systems are crucial for developing targeted therapies.
  • A multidisciplinary, translational approach is vital for optimizing patient outcomes in CCLA.