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Updated: Jun 28, 2025

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Oncotherapy resistance explained by Darwinian and Lamarckian models

Yogen Saunthararajah

    The Journal of Clinical Investigation
    |April 15, 2024
    PubMed
    Summary

    Leukemia cells resistant to CD19 CAR-T therapy show reduced CD19 and CD22 expression. These cells are sensitive to targeted kinase inhibition, suggesting epigenetic changes drive resistance.

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