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Related Concept Videos

Taste Buds and Receptors01:20

Taste Buds and Receptors

1.9K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
1.9K
The Physiology of Taste01:24

The Physiology of Taste

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The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
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Related Experiment Video

Updated: Jun 28, 2025

Measuring Oral Fatty Acid Thresholds, Fat Perception, Fatty Food Liking, and Papillae Density in Humans
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Measuring Oral Fatty Acid Thresholds, Fat Perception, Fatty Food Liking, and Papillae Density in Humans

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The Obese Taste Bud study: Objectives and study design.

Alexander Kersten1, Andrea Lorenz2, Cita Nottmeier3

  • 1Department of Medicine III, Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig, Leipzig, Germany.

Diabetes, Obesity & Metabolism
|April 15, 2024
PubMed
Summary
This summary is machine-generated.

The Obese Taste Bud (OTB) Study links metabolic changes to taste and smell perception in obesity. Findings suggest taste cell homeostasis and perception are crucial factors in understanding and managing obesity.

Keywords:
inflammationmetabolic diseaseobesityoral microbiometaste cell homeostasistaste perception

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Taste Exam: A Brief and Validated Test
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Last Updated: Jun 28, 2025

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Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds
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Area of Science:

  • Metabolic research
  • Obesity science
  • Sensory science

Background:

  • Taste perception significantly influences eating behaviors, body weight regulation, and the development of obesity.
  • The Obese Taste Bud (OTB) Study investigates the intricate relationship between taste cell function and obesity.
  • This prospective cohort study was initiated in 2020 at the University of Leipzig Obesity Centre.

Purpose of the Study:

  • To test the hypothesis that taste cell homeostasis and perception are intrinsically linked to obesity.
  • To elucidate the role of taste perception in the pathophysiology of obesity.
  • To provide a comprehensive understanding of taste perception in the context of weight management.

Main Methods:

  • Participants underwent taste and smell tests, anthropometric measurements, and taste bud density (TBD) assessments.
  • Biomaterial (saliva, blood, tongue swabs, stool) was collected, alongside data on health, diet, and lifestyle.
  • Functional magnetic resonance imaging (fMRI) was employed in a subsample to assess brain responses to eating-related stimuli.

Main Results:

  • Glycated hemoglobin and age showed a negative association with TBD.
  • Unfavorable metabolic profiles, dieting, and vegan diets correlated with altered taste perception.
  • Olfactory function demonstrated a negative correlation with age and high-density lipoprotein cholesterol levels.

Conclusions:

  • Metabolic alterations appear to significantly impact taste and smell function, as well as TBD.
  • The OTB study integrates multi-omics data with physiological and psychological data to advance obesity research.
  • Further understanding of taste perception mechanisms is vital for developing effective obesity interventions.