Dominant lethal study in male mice treated with ofloxacin, a new antimicrobial drug

Ofloxacin (OFLX) in a single dose (250 or 2500 mg/kg) or 5 consecutive daily doses (125 or 1250 mg/kg) produced no dominant lethal mutational effects in male BDF1 strain mice during an 8-week mating schedule. Methyl methanesulfonate (MMS), used as a positive control, produced dominant lethal mutations within 1-3 weeks of mating.