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Updated: Jun 28, 2025

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Piezo1 and Piezo2 collectively regulate jawbone development.

Xuguang Nie1, Yasaman Abbasi1, Man-Kyo Chung1,2

  • 1Department of Neural and Pain Sciences, School of Dentistry, the University of Maryland, Baltimore, MD 21201,USA.

Development (Cambridge, England)
|April 15, 2024
PubMed
Summary
This summary is machine-generated.

Piezo1 and Piezo2 channels are crucial for jawbone development. Their combined disruption in neural crest cells leads to significant jaw malformations and affects cell survival during bone formation.

Keywords:
JawboneMouseNeural crest cellPiezo1Piezo2

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Area of Science:

  • Developmental Biology
  • Mechanobiology
  • Genetics

Background:

  • Piezo1 and Piezo2 are mechanosensory ion channels.
  • These channels are involved in transducing mechanical stimuli into cellular signals.
  • Their role in jawbone development was previously unknown.

Purpose of the Study:

  • To investigate the role of Piezo1 and Piezo2 in jawbone development.
  • To determine the function of these channels in neural crest cell derivatives.
  • To explore the impact of Piezo channel activity on osteogenesis and cell survival.

Main Methods:

  • Utilized mouse models with targeted deletion of Piezo1 and Piezo2 in neural crest cells.
  • Performed histological analyses and TUNEL assays to assess jawbone development and cell death.
  • Administered Yoda1, a Piezo1 agonist, to evaluate its effect on mandibular mineralization.

Main Results:

  • Piezo1 and Piezo2 are robustly expressed during jawbone development.
  • Deletion of Piezo1 in neural crest cells caused jawbone malformations.
  • Double knockout of Piezo1 and Piezo2 resulted in more severe jaw defects, vascular smooth muscle malformations, and increased cell death in osteogenic cells.
  • Yoda1 treatment promoted mandibular mineralization.

Conclusions:

  • Piezo1 and Piezo2 play essential, partially redundant roles in jawbone formation and maintenance.
  • These channels regulate cell survival during osteogenesis in the developing jaw.
  • Piezo channels are critical regulators of craniofacial development.