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Related Concept Videos

Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

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Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
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Spindle Assembly02:50

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Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...
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Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
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Microtubules are dynamic structures that undergo continuous assembly and disassembly. They originate from specialized multi-protein complexes known as microtubule organizing centers or MTOCs. Within the MTOC, the point of origin of the microtubule is known as the minus end, while the end radiating outward is the plus end. Microtubules serve two primary functions — the organization of spindle complexes to separate sister chromatids during mitotic or meiotic cell division and the formation...
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Microtubules in Cell Motility01:24

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Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
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Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
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Updated: Jan 17, 2026

Assembly of Complex Microtubule Structures
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Suniya Luthar (1958-2023).

Jacob A Burack1

  • 1McGill University.

The American Psychologist
|April 15, 2024
PubMed
Summary
This summary is machine-generated.

Suniya Luthar

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Area of Science:

  • Psychology
  • Child Development
  • Maternal Well-being

Background:

  • Suniya Luthar, a distinguished professor and founder of Authentic Connections Groups, dedicated her career to understanding youth resilience.
  • Her research spanned diverse economic backgrounds, focusing on factors influencing children's psychological development.

Purpose of the Study:

  • To investigate the critical link between maternal well-being and children's resilience.
  • To highlight Luthar's final empirical and community work focused on supporting mothers.

Main Methods:

  • Development and implementation of relational group therapy for mothers with addiction and mental illness.
  • Establishment of the evidence-based Authentic Connections Groups program in various settings.

Main Results:

  • Empirical evidence demonstrating that a mother's well-being is intrinsically linked to her child's resilience.
  • Successful application of community interventions to foster maternal support and enhance child outcomes.

Conclusions:

  • Maternal well-being is a cornerstone of child resilience.
  • Luthar's legacy includes impactful programs supporting vulnerable mothers and children.