zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma

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Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
04:20

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

Published on: February 9, 2024

926

Xiuyun Zhang1, Junpeng Hou2, Guangyuan Zhou3

  • 1Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, 430000, China.

Journal of Cancer Research and Clinical Oncology
|April 15, 2024
PubMed
Abstract

Insights

zDHHC3 is down-regulated in kidney clear cell carcinoma (KIRC), and its targeting may offer new therapeutic options. This study reveals zDHHC3 regulates SLC9A2 S-palmitoylation, impacting KIRC progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Kidney clear cell carcinoma (KIRC) presents significant challenges due to poor prognosis and limited therapeutic targets.
  • The role of zDHHC3, implicated in other cancers, is not well-defined in KIRC.

Purpose of the Study:

  • To investigate the role and mechanism of zDHHC3 in kidney clear cell carcinoma.
  • To identify potential therapeutic targets within the zDHHC3 pathway in KIRC.

Main Methods:

  • Pan-cancer analysis and bioinformatics approaches were employed.
  • Cell experiments were conducted to validate findings in KIRC models.
  • Hub genes associated with zDHHC3 expression in KIRC were identified.

Main Results:

  • zDHHC3 expression was significantly downregulated in KIRC, correlating with better patient outcomes.
  • A network of 202 hub genes linked to zDHHC3 expression in KIRC was identified, primarily involved in ion transport.
  • SLC9A2 was identified as a downstream target of zDHHC3, with its expression and S-palmitoylation reduced upon zDHHC3 suppression, inhibiting Caki-2 cell apoptosis.

Conclusions:

  • zDHHC3 plays a crucial role in KIRC, partly through regulating SLC9A2 S-palmitoylation.
  • The zDHHC3-SLC9A2 axis represents a potential novel therapeutic strategy for KIRC treatment.
Keywords:
ApoptosisKidney renal clear cell carcinomaS-palmitoylationSLC9A2zDHHC3

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