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Related Experiment Videos

Spontaneous feminization and menstrual function developing during puberty in Turner's syndrome.

J P Lock, G Henry, R Gotlin

    Obstetrics and Gynecology
    |October 1, 1979
    PubMed
    Summary

    This study details a rare case of Turner syndrome in an 18-year-old female experiencing cyclical bleeding and secondary sexual development. Despite a 45,XO karyotype, she exhibited unique hormonal profiles and gonadal structures.

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    Area of Science:

    • Endocrinology
    • Genetics
    • Reproductive Medicine

    Background:

    • Turner syndrome (45,XO) typically presents with gonadal dysgenesis and lack of secondary sexual characteristics.
    • This case involves an 18-year-old patient with classic Turner phenotype and cyclical vaginal bleeding.

    Observation:

    • The patient displayed spontaneous secondary sexual development and normal estrogen levels.
    • Elevated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were observed, typical of postmenopausal women.
    • Hormonal dynamic testing showed abnormal responses to human menopausal gonadotropin (hMG), human chorionic gonadotropin (hCG), and exaggerated LH-RH stimulation.

    Findings:

    • Karyotyping confirmed a 45,XO karyotype in lymphocytes, skin, and gonadal tissue, ruling out mosaicism.

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  • Endometrial hyperplasia was diagnosed via dilatation and curettage.
  • Histological examination of the gonadal structures revealed lutein cysts.

    • Implications:

    • This case highlights the complex and variable endocrine and reproductive presentations possible in Turner syndrome.
    • It underscores the importance of thorough hormonal and genetic evaluation in atypical presentations of Turner syndrome.
    • The findings contribute to understanding the spectrum of gonadal function and potential pathology in 45,XO individuals.