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The Relationship Between Chromosomal Polymorphism and Male Reproductive Abnormalities
Cui Chen1, Junyi Jiang1, Qin Yang2
1Department of Reproductive Medicine, Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Reproductive Sciences (Thousand Oaks, Calif.)
|April 15, 2024
Summary
Chromosomal polymorphisms, especially Y chromosome variants, are significantly more common in men seeking fertility treatment. These genetic variations are linked to higher rates of infertility, miscarriage, and poor sperm quality.
Area of Science:
- Reproductive Medicine
- Human Genetics
- Clinical Diagnostics
Background:
- Chromosomal polymorphisms are genetic variations that can influence an individual's health.
- Male reproductive health is a complex area influenced by various genetic and environmental factors.
- Understanding the prevalence and impact of chromosomal abnormalities is crucial for fertility assessments.
Purpose of the Study:
- To investigate the association between chromosomal polymorphisms and male reproductive health outcomes.
- To determine the prevalence of chromosomal polymorphisms in males seeking fertility services.
- To compare clinical outcomes between males with and without chromosomal polymorphisms.
Main Methods:
- A cohort of 10,827 males seeking fertility services were analyzed.
- Peripheral blood chromosomal karyotype analysis was performed to identify polymorphisms.
- A control group of 1,630 males with normal karyotypes was established for comparison.
Main Results:
- Chromosomal polymorphisms were detected in 14.98% of the study cohort, significantly higher than the general population (1.77%).
- Y chromosome variants were the most common polymorphism (9.99% prevalence).
- The polymorphism group showed significantly higher rates of spontaneous abortion (18.06% vs. 1.35%), fetal anomalies (1.97% vs. 0.25%), and poor sperm quality (41.74% vs. 7.18%).
Conclusions:
- Chromosomal polymorphisms are significantly associated with male infertility and adverse reproductive outcomes.
- Y chromosome variants are a prevalent finding in males with fertility issues.
- Routine screening for chromosomal polymorphisms may improve reproductive health assessments and management.
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