Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Intentional vital root transection: a 52-week histopathologic study in Macaca mulatta.

R Hitchcock, E Ellis, C F Cox

Oral Surgery, Oral Medicine, and Oral Pathology

|July 1, 1985

Summary

Intentional vital root transection in monkeys led to pulpal degeneration and replacement by periodontal ligament-like tissue. This process resulted in root canal obliteration, significantly reducing pulp chamber blood supply over one year.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Equivalence of virtual and physical model surgery on digitally fabricated models for occlusal planning in segmental maxillary osteotomy.

International journal of oral and maxillofacial surgery·2026

Same author

Prophylactic cosyntropin after unintentional dural puncture and incidence of post-dural puncture headache and epidural blood patch use: A retrospective cohort study (2019-2022).

International journal of obstetric anesthesia·2024

Same author

Effectiveness of different treatments for odontogenic keratocyst: a network meta-analysis.

International journal of oral and maxillofacial surgery·2022

Same author

Regulation of bile acid metabolism in biliary atresia: reduction of FGF19 by Kasai portoenterostomy and possible relation to early outcome.

Journal of internal medicine·2020

Same author

Curcumin induced oxidative stress attenuation by N-acetylcysteine co-treatment: a fibroblast and epithelial cell in-vitro study in idiopathic pulmonary fibrosis.

Molecular medicine (Cambridge, Mass.)·2019

Same author

The molecular characterisation of Cryptosporidium species in relinquished dogs in Great Britain: a novel zoonotic risk?

Parasitology research·2018

Area of Science:

Endodontics
Oral Surgery
Dental Histology

Background:

Surgically mobilized dentoalveolar segments can involve vital root transection.
Previous studies noted variable pulpal responses to root transection.

Purpose of the Study:

To investigate pulpal and periapical tissue responses to intentional vital root transection.
To evaluate these responses over a 1-year postoperative period in a primate model.

Main Methods:

Surgical transection of tooth roots in the apical third in Macaca mulatta monkeys.
Histologic preparation and examination of dental tissues at multiple time points post-surgery (1-52 weeks).

Main Results:

Observed disruption of normal pulpal architecture and initial degeneration.

Related Experiment Videos

Noted replacement of degenerated pulp by periodontal ligament-like tissue.

Documented cellular cemental lining and progressive cementum deposition, leading to root canal obliteration.

Conclusions:

Vital root transection triggers a reparative process involving periodontal ligament-like tissue.
This process leads to significant root canal and pulp chamber obliteration.
The remaining blood supply to the pulp chamber is substantially reduced but remains intact.