Gingival hyperplasia induced by nifedipine, an arterial vasodilating drug

In a 32-year-old patient a relationship was suggested between the development of gingival hyperplasia and the vasodilating drug nifedipine (Adalat). The hyperplasia was clinically and histologically similar to the gingival hyperplasia previously noticed with diphenylhydantoin. The nifedipine-induced gingival hyperplasia may be caused by alterations in calcium metabolism.