Related Experiment Video

Updated: Jun 28, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.8K

HLA genetic polymorphisms and prognosis of patients with COVID-19

L Lorente1, M M Martín2, A Franco3

  • 1Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n., La Laguna 38320, Santa Cruz de Tenerife, Spain.

Medicina Intensiva
|April 15, 2024
PubMed

Insights

Human leukocyte antigen (HLA) genetic variations may influence coronavirus disease 2019 (COVID-19) mortality. Specific HLA alleles were associated with increased mortality risk in COVID-19 patients, warranting further investigation with larger cohorts.

Area of Science:

  • Immunogenetics
  • Infectious Disease Epidemiology

Background:

  • Human leukocyte antigen (HLA) genetic polymorphisms are linked to autoimmune and infectious disease outcomes.
  • Understanding HLA associations with COVID-19 is crucial for prognosis and risk stratification.

Purpose of the Study:

  • To investigate the association between HLA genetic polymorphisms and COVID-19 susceptibility and mortality.
  • To identify specific HLA alleles that may predict mortality in critically ill COVID-19 patients.

Main Methods:

  • Prospective observational study involving 72 COVID-19 patients and 3886 healthy controls.
  • Determination of HLA genetic polymorphisms.
  • Logistic regression analysis to assess the association between HLA alleles and 30-day mortality, controlling for severity scores (SOFA, APACHE-II).

Main Results:

  • A trend suggested differences in certain HLA alleles between COVID-19 patients and healthy controls, though not statistically significant after multiple comparison correction.
  • Logistic regression identified associations between specific HLA alleles (HLA-A*11, HLA-C*01, HLA-DQB1*04) and increased 30-day mortality in COVID-19 patients, even after adjusting for disease severity.

Conclusions:

  • Preliminary findings suggest a potential link between HLA genetic polymorphisms and COVID-19 mortality.
  • Larger-scale studies are necessary to confirm these associations and draw definitive conclusions regarding the role of HLA in COVID-19 outcomes.
Abstract

Keywords:
COVID-19Genetic polymorphismsHLAMortalityOutcome

More Related Videos

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

10.1K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.0K

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.0K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.4K
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
565