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Meningoradiculitis post-COVID-19 mRNA vaccination: A case report
Alexandre Landry1, Stéphanie Crapoulet2, Luc H Boudreau3
1Centre de formation médicale du Nouveau-Brunswick, Pavillon J.-Raymond-Frenette, 50 de la Francophonie St., Moncton, NB E1A 7R1, Canada.
Clinical Immunology Communications
|April 15, 2024
Summary
A rare case of meningoradiculitis, a nervous system inflammation, occurred after mRNA COVID-19 vaccination. Prompt treatment led to near-complete recovery, highlighting the importance of recognizing this rare vaccine side effect.
Area of Science:
- Neurology
- Immunology
- Vaccinology
Background:
- mRNA COVID-19 vaccines have demonstrated significant efficacy and safety.
- Vaccine-associated adverse events, though rare, require thorough investigation.
- Previous history of post-vaccination inflammatory arthritis noted.
Observation:
- Patient presented with central and radicular nervous system symptoms 4 days post-vaccination.
- Symptoms included L5 nerve root deficits, headache, and cognitive difficulties.
- MRI revealed bilateral L5 nerve root enhancement; lumbar puncture showed elevated protein and IgG.
Findings:
- Diagnosis of meningoradiculitis following mRNA COVID-19 vaccination.
- Exclusion of common infectious and inflammatory etiologies.
- Evidence suggests a possible overactive immune response secondary to vaccination.
Implications:
- Meningoradiculitis is a rare but potential adverse event post-vaccination.
- Early recognition and treatment (prednisone, physical therapy) are crucial for recovery.
- This case does not negate the overall benefits of COVID-19 vaccination but emphasizes vigilant monitoring.
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